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Localization of intestinal intraepithelial T lymphocytes involves regulation of αEβ7 expression by transforming growth factor‐β

1 Apr 2002

Abstract excerpt

Induction of alphaEbeta7 expression on T cells by transforming growth factor (TGF)-beta is thought to be important for intestinal intraepithelial T lymphocyte (IEL) entry into the epithelial compartment. However, there has been no in vivo evidence that up-regulation of alphaEbeta7 expression on T cells by TGF-beta is critical for the selective localization of intestinal IEL in the epithelial area. We have...

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PMID: 11934870
DOI: 10.1093/intimm/14.4.339

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