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Article

Down‐regulation of oestrogen receptor‐β associates with transcriptional co‐regulator PATZ1 delocalization in human testicular seminomas

5 Jan 2011

Abstract excerpt

Oestrogen exposure has been linked to a risk for the development of testicular germ cell cancers. The effects of oestrogen are now known to be mediated by oestrogen receptor-α (ERα) and ERβ subtypes, but only ERβ has been found in human germ cells of normal testis. However, its expression was markedly diminished in seminomas, embryonal cell carcinomas and mixed germ cell tumours, but remains high in teratomas....

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Identifiers

PMID: 21381029
DOI: 10.1002/path.2846

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