Article
Chlamydia psittaci-negative ocular adnexal marginal zone B-cell lymphomas have biased VH4-34 immunoglobulin gene expression and proliferate in a distinct inflammatory environment.
Leukemia - 1 Jul 2012
van Maldegem F, Wormhoudt T A M, Mulder M M S, Oud M E C M, Schilder-Tol E, Musler A R, Aten J, Saeed P, Kersten M J, Pals S T, van Noesel C J M, Bende R J
Abstract excerpt
Ocular adnexal marginal zone B-cell lymphomas (OAMZLs) arise in the connective tissues of the orbit or in the mucosa-associated lymphoid tissue of the conjunctiva. Here, we present the immunological and genetic analyses of 20 primary Chlamydia psittaci (Cp)-negative OAMZLs. Analysis of the immunoglobulin variable heavy chain (IgV(H)) gene usage demonstrated a significant preference for V(H)4-34. A combined...
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