Article
Biased use of the IGHV4 family and evidence for antigen selection in Chlamydophila psittaci-negative ocular adnexal extranodal marginal zone lymphomas.
PloS one - 1 Jan 2011
Zhu Daxing, Lossos Chen, Chapman-Fredricks Jennifer R, Matthews Julie M, Ikpatt Offiong F, Ruiz Phillip, Lossos Izidore S
Abstract excerpt
Extranodal marginal zone lymphomas (EMZL) are the most common lymphomas in the ocular adnexa. The etiology and potential role for antigenic stimulation in these lymphomas are still controversial. We have examined IGHV gene usage and mutations in 67 Chlamydophila psittaci-negative ocular adnexal EMZL. Clonal IGHV gene sequences were identified in 43 tumors originating from the orbit (19), conjunctivae (18) and...
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