Article
MTHFR C677T, MTHFR A1298C, and OPG A163G polymorphisms in Mexican patients with rheumatoid arthritis and osteoporosis.
Disease markers - 1 Jan 2012
Brambila-Tapia Aniel Jessica Leticia, Durán-González Jorge, Sandoval-Ramírez Lucila, Mena Juan Pablo, Salazar-Páramo Mario, Gámez-Nava Jorge Iván, González-López Laura, Lazalde-Medina B Brissia, Dávalos Nory Omayra, Peralta-Leal Valeria, Vázquez del Mercado Mónica, Beltrán-Miranda Claudia Patricia, Dávalos Ingrid Patricia
Abstract excerpt
MTHFR polymorphisms C677T and A1298C are associated with reduced MTHFR enzyme activity and hyperhomocysteinemia, which has been associated with osteoporosis. The A163G polymorphism in osteoprotegerin (OPG) has been studied in osteoporosis with controversial results. The objective of the present s...
Topics
- Adult
- Aged
- Arthritis, Rheumatoid
- Bone Density
- Female
- Femur Neck
- Genetic Association Studies
- Haplotypes
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Mexico
- Middle Aged
- Osteoporosis