Article
Allele-specific genetic interactions between Mitf and Kit affect melanocyte development.
Pigment cell & melanoma research - 1 Jun 2010
Wen Bin, Chen Yu, Li Huirong, Wang Jing, Shen Jie, Ma Aobo, Qu Jia, Bismuth Keren, Debbache Julien, Arnheiter Heinz, Hou Ling
Abstract excerpt
The tyrosine kinase receptor KIT and the transcription factor MITF, each required for melanocyte development, have been shown to interact functionally both in vitro and in vivo. In vitro, KIT signaling leads to MITF phosphorylation, affecting MITF activity and stability. In vivo, the presence of the Mitf (Mi-wh) allele exacerbates the spotting phenotype associated with heterozygosity for Kit mutations. Here, we...
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