Article
Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12.
American journal of human genetics - 9 Mar 2012
Kurreeman Fina A S, Stahl Eli A, Okada Yukinori, Liao Katherine, Diogo Dorothée, Raychaudhuri Soumya, Freudenberg Jan, Kochi Yuta, Patsopoulos Nikolaos A, Gupta Namrata, Sandor Cynthia, Bang So-Young, Lee Hye-Soon, Padyukov Leonid, Suzuki Akari, Siminovitch Kathy, Worthington Jane, Gregersen Peter K, Hughes Laura B, Reynolds Richard J, Bridges S Louis, Bae Sang-Cheol, Yamamoto Kazuhiko, Plenge Robert M
Abstract excerpt
We have previously shown that rheumatoid arthritis (RA) risk alleles overlap between different ethnic groups. Here, we utilize a multiethnic approach to show that we can effectively discover RA risk alleles. Thirteen putatively associated SNPs that had not yet exceeded genome-wide significance (p < 5 × 10(-8)) in our previous RA genome-wide association study (GWAS) were analyzed in independent sample sets...
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