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Article

Isoform-specific toxicity of Mecp2 in postmitotic neurons: suppression of neurotoxicity by FoxG1.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Feb 2012

Dastidar Somasish Ghosh, Bardai Farah H, Ma Chi, Price Valerie, Rawat Varun, Verma Pragya, Narayanan Vinodh, D'Mello Santosh R

Abstract excerpt

The methyl-CpG binding protein 2 (MeCP2) is a widely expressed protein, the mutations of which cause Rett syndrome. The level of MeCP2 is highest in the brain where it is expressed selectively in mature neurons. Its functions in postmitotic neurons are not known. The MeCP2 gene is alternatively spliced to generate two proteins with different N termini, designated as MeCP2-e1 and MeCP2-e2. The physiological...

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Identifiers

PMID: 22357867
DOI: 10.1523/JNEUROSCI.5841-11.2012
PMCID: PMC3403752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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