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Article

Apoptotic Activity of MeCP2 Is Enhanced by C-Terminal Truncating Mutations.

PloS one - 1 Jan 2016

Williams Alison A, Mehler Vera J, Mueller Christina, Vonhoff Fernando, White Robin, Duch Carsten

Abstract excerpt

Methyl-CpG binding protein 2 (MeCP2) is a widely abundant, multifunctional protein most highly expressed in post-mitotic neurons. Mutations causing Rett syndrome and related neurodevelopmental disorders have been identified along the entire MECP2 locus, but symptoms vary depending on mutation type and location. C-terminal mutations are prevalent, but little is known about the function of the MeCP2 C-terminus. We...

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Identifiers

PMID: 27442528
DOI: 10.1371/journal.pone.0159632
PMCID: PMC4956225

Genes

MECP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Apoptotic Activity of MeCP2 Is Enhanced by C-Terminal Truncating Mutations.PMID 27442528Read ↗

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