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Article

Methyl CpG-binding protein isoform MeCP2_e2 is dispensable for Rett syndrome phenotypes but essential for embryo viability and placenta development.

The Journal of biological chemistry - 20 Apr 2012

Itoh Masayuki, Tahimic Candice G T, Ide Shuhei, Otsuki Akihiro, Sasaoka Toshikuni, Noguchi Shigeru, Oshimura Mitsuo, Goto Yu-ichi, Kurimasa Akihiro

Abstract excerpt

Methyl CpG-binding protein 2 gene (MeCP2) mutations are implicated in Rett syndrome (RTT), one of the common causes of female mental retardation. Two MeCP2 isoforms have been reported: MeCP2_e2 (splicing of all four exons) and MeCP2_e1 (alternative splicing of exons 1, 3, and 4). Their relative e...

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Identifiers

PMID: 22375006
DOI: 10.1074/jbc.M111.309864
PMCID: PMC3340147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22375006-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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