Article
Using known QTLs to detect directional epistatic interactions.
Genetics research - 1 Feb 2012
Slatkin Montgomery, Kirkpatrick Mark
Abstract excerpt
Epistasis plays important roles in evolution, for example in the evolution of recombination, but each of the current methods to study epistasis has limitations. Here, we propose a new strategy. If a quantitative trait locus (QTL) affecting a quantitative character has been identified, individuals who have the same genotype at that QTL can be regarded as comprising a subpopulation whose response to selection...
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