Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age modulates the effect of COMT genotype on delay discounting behavior.

Psychopharmacology - 1 Aug 2012

Smith Christopher T, Boettiger Charlotte A

Abstract excerpt

RATIONALE AND OBJECTIVE: A form of impulsivity, the tendency to choose immediate over delayed rewards (delay-discounting) has been associated with a single nucleotide polymorphism (SNP) in the catechol-O-methyltransferase (COMT) gene (COMTval¹⁵⁸met; rs4680). However, the existing data regarding the nature of this association are in conflict. We have previously reported that adults homozygous for valine (val) at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Age Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alleles

Share to Catechol O-Methyltransferase

Share to Cross-Sectional Studies

Share to Genotype

Share to Impulsive Behavior

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 22349272
DOI: 10.1007/s00213-012-2653-9
PMCID: PMC3401276

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age modulates the effect of COMT genotype on delay discounting behavior.PMID 22349272Read ↗

Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestrySemantic proximity Read ↗

Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry.Semantic proximity Read ↗

Steep Discounting of Future Rewards as an Impulsivity Phenotype: A Concise Review.Semantic proximity Read ↗

The genetics of impulsivity: evidence for the heritability of delay discounting.Semantic proximity Read ↗

Effects of acute dopamine precusor depletion on immediate reward selection bias and working memory depend on catechol-O-methyltransferase genotype.Semantic proximity Read ↗

Individual differences in dopamine are associated with reward discounting in clinical groups but not in healthy adultsSemantic proximity Read ↗

Catechol-o-methyl transferase modulates cognition in late life: evidence and implications for cognitive enhancement.Semantic proximity Read ↗

Variations in the catechol O-methyltransferase polymorphism and prefrontally guided behaviors in adolescents.Semantic proximity Read ↗

Genome-wide association study of delay discounting in Heterogenous Stock ratsSemantic proximity Read ↗

The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism.Semantic proximity Read ↗

COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis.Semantic proximity Read ↗

Polymorphic variation in the dopamine D4 receptor predicts delay discounting as a function of childhood socioeconomic status: evidence for differential susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.