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Article

Mutations in human αA-crystallin/sHSP affect subunit exchange interaction with αB-crystallin.

PloS one - 1 Jan 2012

Raju Ilangovan, Oonthonpan Lalita, Abraham Edathara C

Abstract excerpt

BACKGROUND: Mutation in αA-crystallin contributes to the development of congenital cataract in humans. Heterooligomerization of αA-crystallin and αB-crystallin is essential for maintaining transparency in the eye lens. The effect of congenital cataract causing mutants of αA-crystallin on subunit exchange and interaction with αB-crystallin is unknown. In the present study, interaction of the mutants of...

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PMID: 22347476
DOI: 10.1371/journal.pone.0031421
PMCID: PMC3275625

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CFP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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