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Article

A translation inhibitor identified in a Drosophila screen enhances the effect of ionizing radiation and taxol in mammalian models of cancer.

Disease models & mechanisms - 1 May 2012

Gladstone Mara, Frederick Barbara, Zheng Di, Edwards Anthony, Yoon Petros, Stickel Stefanie, DeLaney Tessie, Chan Daniel C, Raben David, Su Tin Tin

Abstract excerpt

We described previously a screening protocol in Drosophila melanogaster that allows us to identify small molecules that increase the killing effect of ionizing radiation in vivo in a multicellular context. The ability of this screen to identify agents that enhance the effect of radiation in human cancer models has been validated in published proof-of-concept studies. Here we describe an agent, identified by...

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Identifiers

PMID: 22344740
DOI: 10.1242/dmm.008722
PMCID: PMC3339828

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