Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synthetic protection short interfering RNA screen reveals glyburide as a novel radioprotector.

Radiation research - 1 Oct 2009

Jiang Jianfei, McDonald Peter R, Dixon Tracy M, Franicola Darcy, Zhang Xichen, Nie Suhua, Epperly Laura D, Huang Zhentai, Kagan Valerian E, Lazo John S, Epperly Michael W, Greenberger Joel S

Abstract excerpt

To assist in screening existing drugs for use as potential radioprotectors, we used a human unbiased 16,560 short interfering RNA (siRNA) library targeting the druggable genome. We performed a synthetic protection screen that was designed to identify genes that, when silenced, protected human glioblastoma T98G cells from gamma-radiation-induced cell death. We identified 116 candidate protective genes, then...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colony-Forming Units Assay
Share to Drug Evaluation, Preclinical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Library

Share to Glyburide

Share to Hematopoiesis

Share to Hypoglycemic Agents

Share to Radiation, Ionizing

Share to Whole-Body Irradiation

Source

Open in PubMed Open full text

Identifiers

PMID: 19772462
DOI: 10.1667/RR1674.1
PMCID: PMC2782411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synthetic protection short interfering RNA screen reveals glyburide as a novel radioprotector.PMID 19772462Read ↗

Identification and Biological Evaluation of a Novel and Potent Small Molecule Radiation Sensitizer via an Unbiased Screen of a Chemical LibrarySemantic proximity Read ↗

Screening Immunotherapy Targets to Counter Radiation-Induced NeuroinflammationSemantic proximity Read ↗

Identification of Novel Radiosensitizers in a High-Throughput, Cell-Based Screen for DSB Repair InhibitorsSemantic proximity Read ↗

A translation inhibitor identified in a Drosophila screen enhances the effect of ionizing radiation and taxol in mammalian models of cancer.Semantic proximity Read ↗

RSL3 sensitizes glioma cells to ionizing radiation by suppressing TGM2-dependent DNA damage repair and epithelial-mesenchymal transitionSemantic proximity Read ↗

G-quadruplex stabilizer CX-5461 effectively combines with radiotherapy to target α-thalassemia/mental retardation X-linked-deficient malignant gliomaSemantic proximity Read ↗

Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL InhibitionSemantic proximity Read ↗

Synthetic small molecules that control stem cell fate.Semantic proximity Read ↗

Glibenclamide Directly Prevents Neuroinflammation by Targeting SUR1-TRPM4-Mediated NLRP3 Inflammasome Activation in MicrogliaSemantic proximity Read ↗

Histone Deacetylase Inhibitors: Development of Suberoylanilide Hydroxamic Acid (SAHA) for the Treatment of CancersSemantic proximity Read ↗

A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumorsSemantic proximity Read ↗

Induction of G1 Cell Cycle Arrest in Human Glioma Cells by Salinomycin Through Triggering ROS-Mediated DNA Damage In Vitro and In VivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.