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Article

The influence of fluorouracil outcome parameters on tolerance and efficacy in patients with advanced colorectal cancer.

The pharmacogenomics journal - 1 Aug 2008

Capitain O, Boisdron-Celle M, Poirier A-L, Abadie-Lacourtoisie S, Morel A, Gamelin E

Abstract excerpt

The purpose of this study was to determine simple genetic factors helpful to tailor 5-FU administration and determine strategy in first-line chemotherapy of advanced colorectal cancer. In 76 patients initially treated by 5-FU, thymidylate synthase, dihydropyrimidine dehydrogenase and methylene te...

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Source

Identifiers

PMID: 17700593
DOI: 10.1038/sj.tpj.6500476

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17700593-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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