Article
Genetic variants influencing fluoropyrimidine based-therapy and available methods to detect them.
European review for medical and pharmacological sciences - 1 Mar 2012
Di Francia R, Cimino L, Berretta M
Abstract excerpt
BACKGROUND: Many clinicians acknowledge the importance of genetics in drug response and are favourable about using genetic tests to guide therapy. The 5-Fluorouracil (5-FU) is the backbone of different regimens for the treatment of several solid tumours. Unlikely, some patients develop gastrointestinal and hematologic toxicities when treated by the 5-FU, leading to the suspension of therapy. Current evidences of...
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