Article
Expression profiling of uterine leiomyomata cytogenetic subgroups reveals distinct signatures in matched myometrium: transcriptional profilingof the t(12;14) and evidence in support of predisposing genetic heterogeneity.
Human molecular genetics - 15 May 2012
Hodge Jennelle C, Kim Tae-Min, Dreyfuss Jonathan M, Somasundaram Priya, Christacos Nicole C, Rousselle Marissa, Quade Bradley J, Park Peter J, Stewart Elizabeth A, Morton Cynthia C
Abstract excerpt
Uterine leiomyomata (UL), the most common neoplasm in reproductive-age women, are classified into distinct genetic subgroups based on recurrent chromosome abnormalities. To develop a molecular signature of UL with t(12;14)(q14-q15;q23-q24), we took advantage of the multiple UL arising as independent clonal lesions within a single uterus. We compared genome-wide expression levels of t(12;14) UL to non-t(12;14) UL...
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