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Article

The impairment of reproduction in db/db mice is not mediated by intraovarian defective leptin signaling.

Fertility and sterility - 1 May 2012

Zhang Yuehui, Hu Min, Ma Hongxia, Qu Junwei, Wang Yong, Hou Lihui, Liu Li, Wu Xiao-Ke

Abstract excerpt

OBJECTIVE: To demonstrate whether leptin modulates reproduction by a direct effect within the ovary. DESIGN: Animal model. SETTING: National Key Laboratory of Infertility. ANIMAL(S): Adult female db/db mice. INTERVENTION(S): Adult littermate wild-type (WT) and diabetic (db) leptin receptor (LR) mutant female mice were matched for the allograft of the ovary to construct new genotypic models, respectively. WT mouse...

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PMID: 22341640
DOI: 10.1016/j.fertnstert.2012.01.126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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