Estrogenic stimulation of ovarian follicular maturation in diabetes (db/db) mutant mice: restoration of euglycemia prevents hyperlipidemic cytoatrophy.

doi:10.1007/s00441-004-0967-6

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Article

Estrogenic stimulation of ovarian follicular maturation in diabetes (db/db) mutant mice: restoration of euglycemia prevents hyperlipidemic cytoatrophy.

Cell and tissue research - 1 Nov 2004

Garris David R

Abstract excerpt

The diabetes (db/db) mutation (leptin-receptor defect) induces a hyperglycemic-hyperinsulinemic endometabolic environment that promotes hypercytolipidemic ovarian involution in C57BL/KsJ mice, resulting in reproductive sterility and eventual organoatrophy. The effectiveness of low-dose (1.0 microg/sc/3.5 day intervals), 17- beta-estradiol therapy (E2-HRx), initiated prior to expression of the overt...

Topics

Animals
Blood Glucose
Diabetes Complications
Diabetes Mellitus
Estradiol
Female
Follicular Atresia
Gene Expression Regulation
Hyperglycemia
Hyperlipidemias
Injections, Subcutaneous
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Mutation
Obesity
Ovarian Follicle

Source

Open in PubMed

Identifiers

PMID: 15503160
DOI: 10.1007/s00441-004-0967-6

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