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Effect of maternal obesity on estrous cyclicity, embryo development and blastocyst gene expression in a mouse model

20 Sept 2012

Abstract excerpt

STUDY QUESTION: Does maternal obesity affect estrous cyclicity, embryo development and blastocyst gene expression in mice? SUMMARY ANSWER: Maternal obesity alters estrous cyclicity and causes the down-regulation of two key metabolite receptors (Slc2a1 and Ldlr) in blastocysts recovered from diet-induced obese females, but embryo development is not affected. WHAT IS KNOWN ALREADY: Maternal obesity reduces...

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PMID: 23001779
DOI: 10.1093/humrep/des327

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