Diabetes (db/db) mutation-induced female reproductive tract hypercytolipidemia: estrogenic restoration of utero-ovarian indices.

doi:10.1016/j.reprotox.2004.04.007

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Article

Diabetes (db/db) mutation-induced female reproductive tract hypercytolipidemia: estrogenic restoration of utero-ovarian indices.

Reproductive toxicology (Elmsford, N.Y.) - 1 Jul 2004

Garris David R, Garris Bryan L

Abstract excerpt

The diabetes (db/db) mutation (leptin-receptor defect) induces a hyperglycemic-hyperinsulinemic endometabolic environment that promotes hypercytolipidemic, utero-ovarian involution in C57BL/KsJ mice, resulting in reproductive sterility and eventual organoatrophy. The effectiveness of low-dose, 17-B-estradiol therapy (E2-HRx), initiated prior to the genetic expression of the overt diabetes-obesity syndrome (DOS)...

Topics

Animals
Atrophy
Body Weight
Diabetes Mellitus
Estradiol
Female
Genotype
Histocytochemistry
Hyperglycemia
Hyperinsulinism
Hyperlipidemias
Insulin
Mice
Mice, Inbred C57BL
Mutation
Obesity
Ovary
Radioimmunoassay

Source

Open in PubMed

Identifiers

PMID: 15219626
DOI: 10.1016/j.reprotox.2004.04.007

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