Article
Modeling SNP mediated differential targeting of homologous 3'UTR by microRNA.
RNA biology - 1 Mar 2012
Ahluwalia Jasmine Kaur, Soni Kartik, Sivasubbu Sridhar, Brahmachari Vani
Abstract excerpt
We had previously proposed that the post-transcriptional regulation through microRNA as a mechanism for incomplete penetrance and variable expressivity, leads to lack of correlation between genotype and phenotype. Here we report the validation of miRNA-target interactions we predicted earlier and demonstrate the regulation of endogenous JAG1 by hsa-miR-214 and hsa-miR-124, and TGFBR2 by hsa-miR-34b*, through...
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