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Article

Microevolution of Cryptococcus neoformans Driven by Massive Tandem Gene Amplification

14 Feb 2012

Abstract excerpt

The subtelomeric regions of organisms ranging from protists to fungi undergo a much higher rate of rearrangement than is observed in the rest of the genome. While characterizing these ~40-kb regions of the human fungal pathogen Cryptococcus neoformans, we have identified a recent gene amplification event near the right telomere of chromosome 3 that involves a gene encoding an arsenite efflux transporter (ARR3)....

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PMID: 22334577
DOI: 10.1093/molbev/mss066

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