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Article

Genome-wide analysis of epistasis in body mass index using multiple human populations.

European journal of human genetics : EJHG - 1 Aug 2012

Wei Wen-Hua, Hemani Gib, Gyenesei Attila, Vitart Veronique, Navarro Pau, Hayward Caroline, Cabrera Claudia P, Huffman Jennifer E, Knott Sara A, Hicks Andrew A, Rudan Igor, Pramstaller Peter P, Wild Sarah H, Wilson James F, Campbell Harry, Hastie Nicholas D, Wright Alan F, Haley Chris S

Abstract excerpt

We surveyed gene-gene interactions (epistasis) in human body mass index (BMI) in four European populations (n<1200) via exhaustive pair-wise genome scans where interactions were computed as F ratios by testing a linear regression model fitting two single-nucleotide polymorphisms (SNPs) with interactions against the one without. Before the association tests, BMI was corrected for sex and age, normalised and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22333899
DOI: 10.1038/ejhg.2012.17
PMCID: PMC3400731

Genes

CDH13
SORCS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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