Article
Ancestral mutations may cause a significant proportion of GCK-MODY.
Pediatric diabetes - 1 Sept 2012
Dusatkova Petra, Pruhova Stepanka, Borowiec Maciej, Vesela Klara, Antosik Karolina, Lebl Jan, Mlynarski Wojciech, Cinek Ondrej
Abstract excerpt
BACKGROUND: Although the literature indicates that ancestral mutations in the glucokinase (GCK) gene are rare, we have detected a high frequency of four prevalent mutations that together are responsible for over one third of the GCK mutations in our Czech National Register of monogenic diabetes. Therefore, we studied their potential ancestral origin in our and neighbouring Polish populations. METHODS: We analysed...
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