Article
Temporal and developmental requirements for the Prader-Willi imprinting center.
Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 2012
DuBose Amanda J, Smith Emily Y, Johnstone Karen A, Resnick James L
Abstract excerpt
Imprinted gene expression associated with Prader-Willi syndrome (PWS) and Angelman syndrome (AS) is controlled by two imprinting centers (ICs), the PWS-IC and the AS-IC. The PWS-IC operates in cis to activate transcription of genes that are expressed exclusively from the paternal allele. We have created a conditional allele of the PWS-IC to investigate its developmental activity. Deletion of the paternal PWS-IC...
Topics
- Alleles
- Animals
- Blastocyst
- Brain
- DNA Methylation
- Disease Models, Animal
- Embryonic Development
- Female
- Gene Expression Regulation, Developmental
- Genomic Imprinting
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains