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Article

Temporal and developmental requirements for the Prader-Willi imprinting center.

Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 2012

DuBose Amanda J, Smith Emily Y, Johnstone Karen A, Resnick James L

Abstract excerpt

Imprinted gene expression associated with Prader-Willi syndrome (PWS) and Angelman syndrome (AS) is controlled by two imprinting centers (ICs), the PWS-IC and the AS-IC. The PWS-IC operates in cis to activate transcription of genes that are expressed exclusively from the paternal allele. We have created a conditional allele of the PWS-IC to investigate its developmental activity. Deletion of the paternal PWS-IC...

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Identifiers

PMID: 22331910
DOI: 10.1073/pnas.1115057109
PMCID: PMC3295271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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