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Mutagenic primer design for mismatch PCR-RFLP SNP genotyping using a genetic algorithm.

IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000

Yang Cheng-Hong, Cheng Yu-Huei, Yang Cheng-Huei, Chuang Li-Yeh

Abstract excerpt

Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) is useful in small-scale basic research studies of complex genetic diseases that are associated with single nucleotide polymorphism (SNP). Designing a feasible primer pair is an important work before performing PCR-RFLP for SNP genotyping. However, in many cases, restriction enzymes to discriminate the target SNP resulting in the primer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22331864
DOI: 10.1109/TCBB.2012.25

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