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Article

Characterization of critical domains within the tumor suppressor CASZ1 required for transcriptional regulation and growth suppression.

Molecular and cellular biology - 1 Apr 2012

Virden Ryan A, Thiele Carol J, Liu Zhihui

Abstract excerpt

CASZ1 is a zinc finger (ZF) transcription factor that is critical for controlling the normal differentiation of subtypes of neural and cardiac muscle cells. In neuroblastoma tumors, loss of CASZ1 is associated with poor prognosis and restoration of CASZ1 function suppresses neuroblastoma tumorigenicity. However, the key domains by which CASZ1 transcription controls developmental processes and neuroblastoma...

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Share to Cell Proliferation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, SCID

Share to Neoplasm Transplantation

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Share to Protein Structure, Tertiary

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Source

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Identifiers

PMID: 22331471
DOI: 10.1128/MCB.06039-11
PMCID: PMC3318574

Genes

CASZ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Characterization of critical domains within the tumor suppressor CASZ1 required for transcriptional regulation and growth suppression.PMID 22331471Read ↗

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