Article
Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility.
Antimicrobial agents and chemotherapy - 1 May 2012
Melikian George L, Rhee Soo-Yon, Taylor Jonathan, Fessel W Jeffrey, Kaufman David, Towner William, Troia-Cancio Paolo V, Zolopa Andrew, Robbins Gregory K, Kagan Ron, Israelski Dennis, Shafer Robert W
Abstract excerpt
Determining the phenotypic impacts of reverse transcriptase (RT) mutations on individual nucleoside RT inhibitors (NRTIs) has remained a statistical challenge because clinical NRTI-resistant HIV-1 isolates usually contain multiple mutations, often in complex patterns, complicating the task of determining the relative contribution of each mutation to HIV drug resistance. Furthermore, the NRTIs have highly variable...
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