Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variations in LOXL1 associated with exfoliation glaucoma do not affect amine oxidase activity.

Molecular vision - 1 Jan 2012

Kim Seonkwan, Kim Youngho

Abstract excerpt

PURPOSE: Lysyl oxidase-like 1 (LOXL1) is a copper-dependant amine oxidase that plays an essential role in elastogenesis. Two non-synonymous single-nucleotide polymorphisms of LOXL1, R141L (rs1048661) and G153D (rs3825942), have been reported to significantly increase susceptibility to exfoliation glaucoma (XFG). To evaluate the impact of the R141L and G153D variations on the amine oxidase activity of LOXL1, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amino Acid Oxidoreductases

Share to Exfoliation Syndrome

Share to Fluorometry

Share to Genetic Vectors

Share to Glaucoma, Open-Angle

Share to Isoenzymes

Share to Mutagenesis, Site-Directed

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 22328822
PMCID: PMC3275637

Genes

LOXL1

Variants

rs1048661
rs1048661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variations in LOXL1 associated with exfoliation glaucoma do not affect amine oxidase activity.PMID 22328822Read ↗

Lysyl oxidase-like protein 1 (LOXL1) gene polymorphisms and exfoliation glaucoma in a Central European population.Semantic proximity Read ↗

Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.Semantic proximity Read ↗

LOXL1 genetic polymorphisms are associated with exfoliation glaucoma in the Japanese population.Semantic proximity Read ↗

Lysyl Oxidase Like 1: Biological roles and regulation.Semantic proximity Read ↗

Expression and regulation of LOXL1 and elastin-related genes in eyes with exfoliation syndrome.Semantic proximity Read ↗

Lysyl oxidase-like 1 gene polymorphisms in Japanese patients with primary open angle glaucoma and exfoliation syndrome.Semantic proximity Read ↗

Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma.Semantic proximity Read ↗

Association of LOXL1 gene polymorphisms with exfoliation syndrome/glaucoma and primary open angle glaucoma in a Turkish population.Semantic proximity Read ↗

Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people.Semantic proximity Read ↗

Lysyl oxidase-like 1 polymorphisms and exfoliation syndrome in the Japanese population.Semantic proximity Read ↗

The LOXL1 gene variations are not associated with primary open-angle and primary angle-closure glaucomas.Semantic proximity Read ↗

LOXL1 gene analysis in Turkish patients with exfoliation glaucoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.