Article
Biological roles of nontypeable Haemophilus influenzae type IV pilus proteins encoded by the pil and com operons.
Journal of bacteriology - 1 Apr 2012
Carruthers Michael D, Tracy Erin N, Dickson Amanda C, Ganser Kara B, Munson Robert S, Bakaletz Lauren O
Abstract excerpt
We previously demonstrated that one or more products of the genes in the pil and com gene clusters of the opportunistic human respiratory pathogen nontypeable Haemophilus influenzae (NTHI) are required for type IV pilus (Tfp) biogenesis and function. Here, we have now demonstrated that the pilABCD and comABCDEF gene clusters are operons and that the product of each gene is essential for normal pilus function....
Topics
- Bacterial Adhesion
- Bacterial Proteins
- Biofilms
- Cells, Cultured
- Epithelial Cells
- Fimbriae, Bacterial
- Gene Expression Regulation, Bacterial
- Haemophilus influenzae
- Humans
- Multigene Family
- Mutation
- Operon
- Respiratory Mucosa