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Article

Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation.

Experimental hematology - 1 Oct 2006

Hartman Amy D, Wilson-Weekes Annique, Suvannasankha Attaya, Burgess Gem S, Phillips Carissa A, Hincher Katie J, Cripe Larry D, Boswell H Scott

Abstract excerpt

OBJECTIVE: c-jun N-terminal kinase (JNK) has been implicated in proliferation and survival downstream from the tyrosine kinase oncogene, p210 BCR-ABL, in chronic myeloid leukemia. We studied whether a similar relationship between JNK and FMS-like tyrosine kinase 3 (Flt3) describes acute myeloid leukemia (AML). METHODS: By immunoprecipitation, Flt3 was found to be activated and identified as the potential origin...

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Share to fms-Like Tyrosine Kinase 3
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mitogen-Activated Protein Kinase 8

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Source

Identifiers

PMID: 16982329
DOI: 10.1016/j.exphem.2006.05.019

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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