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Article

APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics.

Neuro-degenerative diseases - 1 Jan 2012

Vitek M P, Christensen D J, Wilcock D, Davis J, Van Nostrand W E, Li F Q, Colton C A

Abstract excerpt

BACKGROUND: After age, the second largest risk factor for Alzheimer's disease (AD) is apolipoprotein E (APOE) genotype, where APOE4 is associated with lower apoE protein levels, more severer brain pathology, enhanced inflammation and disease. Small peptides corresponding to the receptor-binding r...

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Source

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Identifiers

PMID: 22326991
DOI: 10.1159/000334914
PMCID: PMC3363346

Genes

APOE
APP
NOS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22326991-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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