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Article

Imprinted gene dosage is critical for the transition to independent life.

Cell metabolism - 8 Feb 2012

Charalambous Marika, Ferron Sacramento R, da Rocha Simao T, Murray Andrew J, Rowland Timothy, Ito Mitsuteru, Schuster-Gossler Karin, Hernandez Arturo, Ferguson-Smith Anne C

Abstract excerpt

Neonatal survival in mammals is crucially dependent upon maintenance of body temperature. Neonatal body temperature is largely maintained by thermogenesis in brown adipose tissue (BAT). BAT develops perinatally in mice requiring integration of adipogenic and thermoregulatory gene pathways. We describe a regulatory mutation in the imprinted gene cluster on mouse chromosome 12 resulting in early postnatal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22326222
DOI: 10.1016/j.cmet.2012.01.006
PMCID: PMC3314949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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