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Article

Parental origin-specific developmental defects in mice with uniparental disomy for chromosome 12.

Development (Cambridge, England) - 1 Nov 2000

Georgiades P, Watkins M, Surani M A, Ferguson-Smith A C

Abstract excerpt

Genetic analysis has shown that the distal portion of mouse chromosome 12 is imprinted; however, the developmental roles of imprinted genes in this region are not known. We have therefore generated conceptuses with uniparental disomy for chromosome 12, in which both copies of chromosome 12 are either paternally or maternally derived (pUPD12 and mUPD12, respectively). Both types of UPD12 result in embryos that are...

Topics

Aneuploidy
Animals
Bone and Bones
Chromosome Mapping
Congenital Abnormalities
Crosses, Genetic
Embryonic and Fetal Development
Female
Genomic Imprinting
Genotype
Gestational Age

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Muscle, Skeletal

Placenta

Pregnancy

Source

Identifiers

PMID: 11023874
DOI: 10.1242/dev.127.21.4719

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