Article
Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia.
BMC microbiology - 27 Feb 2008
Howden Benjamin P, Smith Danielle J, Mansell Ashley, Johnson Paul D R, Ward Peter B, Stinear Timothy P, Davies John K
Abstract excerpt
BACKGROUND: Low-level vancomycin resistance in Staphylococcus aureus (vancomycin-intermediate S. aureus (VISA) and hetero-VISA [hVISA]) emerges during persistent infection and failed vancomycin therapy. Up-regulation of genes associated with the "cell wall stimulon" and mutations in the vraSR operon have both been implicated in the development of resistance, however the molecular mechanisms of resistance are not...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.