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Honokiol in Combination with Radiation Targets Notch Signaling to Inhibit Colon Cancer Stem Cells

9 Feb 2012

Abstract excerpt

Cancer stem cells are implicated in resistance to ionizing radiation (IR) and chemotherapy. Honokiol, a biphenolic compound has been used in traditional Chinese medicine for treating various ailments. In this study, we determined the ability of honokiol to enhance the sensitivity of colon cancer stem cells to IR. The combination of honokiol and IR suppressed proliferation and colony formation while inducing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22319203
DOI: 10.1158/1535-7163.mct-11-0999

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