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Article

Combined Treatment of Heteronemin and Tetrac Induces Antiproliferation in Oral Cancer Cells

2 Jul 2020

Abstract excerpt

Background: Heteronemin, a marine sesterterpenoid-type natural product, possesses an antiproliferative effect in cancer cells. In addition, heteronemin has been shown to inhibit p53 expression. Our laboratory has demonstrated that the thyroid hormone deaminated analogue, tetrac, activates p53 and induces antiproliferation in colorectal cancer. However, such drug mechanisms are still to be studied in oral cancer...

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PMID: 32630719
DOI: 10.3390/md18070348

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