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Article

Dysregulation of distal cholesterol biosynthesis in association with relapse and advanced disease in CHC genotype 2 and 3 treated with sofosbuvir and ribavirin.

Journal of hepatology - 1 Jan 2016

Younossi Zobair M, Stepanova Maria, Estep Michael, Negro Francesco, Clark Paul J, Hunt Sharon, Song Qinghua, Paulson Matthew, Stamm Luisa M, Brainard Diana M, Subramanian G Mani, McHutchison John G, Patel Keyur

Abstract excerpt

BACKGROUND & AIMS: Hepatitis C virus (HCV) modulates host lipid metabolism for its replication and lifecycle. Our aims were to assess changes in the serum lipid and distal (post-squalene) cholesterol biosynthesis metabolite profile of HCV genotypes (GT) 2 and 3 patients treated with sofosbuvir+ribavirin. METHODS: Serum samples [baseline, treatment week 12, 4weeks post-treatment] were analyzed for apolipoproteins...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26341824
DOI: 10.1016/j.jhep.2015.08.027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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