Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of activated leukocyte cell adhesion molecule-mediated invasion triggers an innate immune gene response in melanoma.

The Journal of investigative dermatology - 1 May 2012

van Kilsdonk Jeroen W J, Takahashi Nozomi, Weidle Ulrich, Burtscher Helmut, Jarry Jonathan, Daha Mohamed R, Swart Guido W M, van Kempen Léon C L T

Abstract excerpt

Activated leukocyte cell adhesion molecule (ALCAM/CD166) is a progression marker of a variety of cancers, including melanoma, and is a marker for mesenchymal stem cells. ALCAM expression triggers matrix metalloproteinase activity and correlates with the transition between superficial melanoma growth and deep dermal invasion in vivo. We previously showed that manipulating ALCAM functionality could both decrease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion
Share to Cell Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Melanoma

Share to Microarray Analysis

Share to Neoplasm Invasiveness

Share to Neoplasm Metastasis

Share to Skin Neoplasms

Source

Identifiers

PMID: 22318386
DOI: 10.1038/jid.2011.487

Genes

ALCAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of activated leukocyte cell adhesion molecule-mediated invasion triggers an innate immune gene response in melanoma.PMID 22318386Read ↗

Attenuation of Melanoma Invasion by a Secreted Variant of Activated Leukocyte Cell Adhesion MoleculeSemantic proximity Read ↗

Novel role for ALCAM in lymphatic network formation and functionSemantic proximity Read ↗

Activated leukocyte cell-adhesion molecule (ALCAM) promotes malignant phenotypes of malignant mesothelioma.Semantic proximity Read ↗

Altered integrin expression patterns shown by microarray in human cutaneous melanomaSemantic proximity Read ↗

Cell Adhesion Molecules in Normal Skin and MelanomaSemantic proximity Read ↗

CD166/activated leukocyte cell adhesion molecule is expressed on glioblastoma progenitor cells and involved in the regulation of tumor cell invasion.Semantic proximity Read ↗

Activin A Sustains the Metastatic Phenotype of Tumor-Associated Macrophages and Is a Prognostic Marker in Human Cutaneous Melanoma.Semantic proximity Read ↗

MNK1 signaling induces an ANGPTL4-mediated gene signature to drive melanoma progression.Semantic proximity Read ↗

ALDH1A1 overexpression in melanoma cells promotes tumor angiogenesis by activating the IL‑8/Notch signaling cascadeSemantic proximity Read ↗

Loss of Ambra1 promotes melanoma growth and invasion.Semantic proximity Read ↗

Activated leukocyte cell adhesion molecule (CD166/ALCAM): Developmental and mechanistic aspects of cell clustering and cell migrationSemantic proximity Read ↗

Melanoma‐derived conditioned media efficiently induce the differentiation of monocytes to macrophages that display a highly invasive gene signatureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.