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Article

The B cell receptor-induced calcium flux involves a calcium mediated positive feedback loop.

Cell calcium - 1 May 2012

Hagen Sandra, Brachs Sebastian, Kroczek Carmen, Fürnrohr Barbara G, Lang Christiane, Mielenz Dirk

Abstract excerpt

The B cell receptor (BCR)-elicited calcium flux results in activation of mature B cells. We have recently shown that the adaptor protein Swiprosin-1/EFhd2 (EFhd2) amplifies the BCR-induced calcium flux in B cell lines. EFhd2 is a calcium binding adaptor protein with two predicted EF-hands. Here we asked whether these domains are functional and control its function. Using a blot-overlay assay with radioactive...

Read the complete abstract on PubMed

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to EF Hand Motifs

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Share to Lymphocyte Activation

Share to Receptors, Antigen, B-Cell

Source

Identifiers

PMID: 22317918
DOI: 10.1016/j.ceca.2012.01.004

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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