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Article

A LASSO-based integrative model of serum biomarkers and gene polymorphisms for predicting poor sepsis prognosis.

Biomarkers in medicine - 1 Oct 2025

Zhang Dalong, Dong Huijun, Wang Yizhe, Hao Zhengtao, Nie Hanxiao, Wang Zhenzhen, Ding Ningyang, Niu Xingguo

Abstract excerpt

BACKGROUND: The integration of serum biomarkers and gene polymorphisms may enhance early prognostic assessment in sepsis. Early and accurate prediction of outcomes is crucial for optimizing treatment strategies and improving survival. However, the clinical utility of combining genetic markers with conventional inflammatory indicators remains insufficiently validated. METHODS: In this retrospective cohort (n = 81;...

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PMID: 41237264
DOI: 10.1080/17520363.2025.2586136
PMCID: PMC12893731

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TLR4
CRP

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