Brush border myosin Ia inactivation in gastric but not endometrial tumors.

doi:10.1002/ijc.27856

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Article

Brush border myosin Ia inactivation in gastric but not endometrial tumors.

International journal of cancer - 15 Apr 2013

Mazzolini Rocco, Rodrigues Paulo, Bazzocco Sarah, Dopeso Higinio, Ferreira Ana M, Mateo-Lozano Silvia, Andretta Elena, Woerner Stefan M, Alazzouzi Hafid, Landolfi Stefania, Hernandez-Losa Javier, Macaya Irati, Suzuki Hiromu, Ramón y Cajal Santiago, Mooseker Mark S, Mariadason John M, Gebert Johannes, Hofstra Robert M W, Reventós Jaume, Yamamoto Hiroyuki, Schwartz Simo, Arango Diego

Abstract excerpt

Brush border Myosin Ia (MYO1A) has been shown to be frequently mutated in colorectal tumors with microsatellite instability (MSI) and to have tumor suppressor activity in intestinal tumors. Here, we investigated the frequency of frameshift mutations in the A8 microsatellite in exon 28 of MYO1A in MSI gastric and endometrial tumors and found a high mutation rate in gastric (22/47; 46.8%) but not endometrial (3/48;...

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PMID: 23002058
DOI: 10.1002/ijc.27856

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