Article
Systematic identification of gene annotation errors in the widely used yeast mutation collections.
Nature methods - 5 Feb 2012
Ben-Shitrit Taly, Yosef Nir, Shemesh Keren, Sharan Roded, Ruppin Eytan, Kupiec Martin
Abstract excerpt
The baker's yeast mutation collections are extensively used genetic resources that are the basis for many genome-wide screens and new technologies. Anecdotal evidence has previously pointed to the putative existence of a neighboring gene effect (NGE) in these collections. NGE occurs when the phenotype of a strain carrying a particular perturbed gene is due to the lack of proper function of its adjacent gene. Here...
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