Article
Genetic variation in TRPS1 may regulate hip geometry as well as bone mineral density.
Bone - 1 May 2012
Ackert-Bicknell Cheryl L, Demissie Serkalem, Tsaih Shirng-Wern, Beamer Wesley G, Cupples L Adrienne, Paigen Beverly J, Hsu Yi-Hsiang, Kiel Douglas P, Karasik David
Abstract excerpt
Trps1 has been proposed as a candidate gene for a mouse bone mineral density (BMD) QTL on Chromosome (Chr) 15, but it remained unclear if this gene was associated with BMD in humans. We used newly available data and advanced bioinformatics techniques to confirm that Trps1 is the most likely candidate gene for the mouse QTL. In short, by combining the raw genetic mapping data from two F2 generation crosses of...
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