Article
Suppression of developmental anomalies by maternal macrophages in mice.
The Journal of experimental medicine - 1 Nov 1990
Nomura T, Hata S, Kusafuka T
Abstract excerpt
We tested whether nonspecific tumoricidal immune cells can suppress congenital malformations by killing precursor cells destined to cause such defects. Pretreatment of pregnant ICR mice with synthetic (Pyran copolymer) and biological (Bacillus Calmette-Guérin) agents significantly suppressed radi...
Topics
- Abnormalities, Drug-Induced
- Abnormalities, Radiation-Induced
- Animals
- Cell Survival
- Congenital Abnormalities
- Embryo, Mammalian
- Female
- Macrophage Activation
- Macrophages
- Maternal-Fetal Exchange
- Methylnitrosourea
- Mice
- Mice, Inbred ICR
- Mutation
- Mycobacterium bovis
- Pregnancy
- Urethane