Article
Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation.
The Journal of biological chemistry - 1 May 2009
Lakshmana Madepalli K, Yoon Il-Sang, Chen Eunice, Bianchi Elizabetta, Koo Edward H, Kang David E
Abstract excerpt
Accumulation of the amyloid beta (Abeta) peptide derived from the proteolytic processing of amyloid precursor protein (APP) is the defining pathological hallmark of Alzheimer disease. We previously demonstrated that the C-terminal 37 amino acids of lipoprotein receptor-related protein (LRP) robustly promoted Abeta generation independent of FE65 and specifically interacted with Ran-binding protein 9 (RanBP9). In...
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