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Article

The identification of gene duplication and the role of secreted aspartyl proteinase 1 in Candida parapsilosis virulence.

The Journal of infectious diseases - 15 Mar 2012

Horváth Péter, Nosanchuk Joshua D, Hamari Zsuzsanna, Vágvölgyi Csaba, Gácser Attila

Abstract excerpt

In this study, we analyzed the role of Candida parapsilosis-secreted aspartyl proteinase isoenzyme 1 (SAPP1) in virulence. The in silico analysis of SAPP1 sequence revealed a 2871 base pair-duplicated region (SAPP1a and SAPP1b) in the genome of C. parapsilosis. We generated homozygous ΔΔsapp1a, ΔΔsapp1b, and ΔΔsapp1a-ΔΔsapp1b mutants. Notably, Sapp1 production in an inducer medium was reduced by approximately 50%...

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Identifiers

PMID: 22301631
DOI: 10.1093/infdis/jir873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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