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Targeted gene deletion in Candida parapsilosis demonstrates the role of secreted lipase in virulence

14 Sept 2007

Abstract excerpt

Candida parapsilosis is a major cause of human disease, yet little is known about the pathogen's virulence. We have developed an efficient gene deletion system for C. parapsilosis based on the repeated use of the dominant nourseothricin resistance marker (caSAT1) and its subsequent deletion by FLP-mediated, site-specific recombination. Using this technique, we deleted the lipase locus in the C. parapsilosis...

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PMID: 17853941
DOI: 10.1172/jci32294

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